pediatric meduloblastoma and the prognostic value of mib-1 proliferative factor

background: medulloblastoma is the most common malignant brain tumor in children. the important factors in predicting survival are the extent of disease, proliferation index of the tumor cells, histopathologic class and the age at diagnosis. the percentage of ki-67 positive cells reflects the proliferation  of the cells and is one of the critical factors which determine the growth of the tumor. monoclonal mib-1 antibody can be targeted against recombinant ki-67 and then demonstrated by immunohistochemical methods. materials and methods: formalin-fixed, paraffin-embedded tissue of 18 pediatric patients with medulloblastoma at mofid